A call for a public, transparent discussion about the risks and benefits of gene editing in human germline cells aims to lay some ground rules and educate the public to prevent a GMO-type backlash.
CohBar has re-opened the book on mitochondrial function with the discovery of a mitochondrial peptide that acts on skeletal muscle and mimics the effect of exercise.
A chimeric form of AAV uses DARPins for customized targeting of gene therapy payloads.
TRANSLATION IN BRIEF
Karyopharm is taking its XPO1 inhibitors, which could have neuroprotective and anti-inflammatory activity in MS, into the clinic for the disease.
Cytokine levels hint that an immune-activating event may trigger chronic fatigue syndrome.
Preclinical studies of PegIntron shows the PK parameters of the compound differ in male and female animals.
THE DISTILLERY brings you this week's most essential scientific findings in therapeutics, distilled by Innovations editors from a weekly review of more than 400 papers in 41 of the highest-impact journals in the fields of biotechnology, the life sciences and chemistry. The Distillery goes beyond the abstracts to explain the commercial relevance of featured research, including licensing status and companies working in the field, where applicable.
This week in therapeutics includes important research findings on targets and compounds, grouped first by disease class and then alphabetically by indication.
This week in techniques includes findings about research tools, disease models and manufacturing processes that have the potential to enable or improve all stages of drug discovery and development.