Publications

Show Filters

Searches all publications.

Search Fulltext

Publications

Section

Select publication to see the relevant sections.

Publication Date

    E.g., 2018-09-24
    E.g., 2018-09-24

Articles

14549 items
12:27 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts PGK1-knockout mice expressing an SP-C variant could be used to study the biology of idiopathic pulmonary fibrosis (IPF) and screen for therapies. Mice with inducible knockout of PGK1 that systemically expressed a...
1:04 PM, Aug 30, 2018  |  BC Innovations | Targets & Mechanisms

Alt-neoantigens

Neoantigens derived from alternative splicing could broaden the target space for cancer vaccines and T cell therapies, according to two studies published this month. While questions remain about whether they are sufficiently immunogenic to create...
11:11 AM, Aug 30, 2018  |  BC Innovations | Translation in Brief

Turning off the inflammasome

In a July Nature paper, a team from the University of California San Diego identified CMPK2 as a potential target for inflammatory diseases involving NLRP3 inflammasomes and may launch a spinout to develop the findings....
10:21 AM, Aug 30, 2018  |  BC Innovations | Tools & Techniques

Master of autism

The discovery of a master regulator of autism risk genes has yielded the first mouse model of the form of the condition that accounts for about 90% of patients, and could spark a new way...
1:49 PM, Aug 29, 2018  |  BC Innovations | Emerging Company Profile

Meta(bolite) analysis

ClostraBio Inc.’s preclinical gut microbiome-derived metabolites could yield a pan-allergen therapy for food allergy, eschewing the need for multiple allergen-specific treatments. Director of Operations John Colson said research from co-founder and President Cathryn Nagler suggests microbial...
11:33 AM, Aug 29, 2018  |  BC Innovations | Translation in Brief

Accelerated healing

In a Science Translational Medicine paper published last month, an NIH team showed SRY (sex determining region Y)-box 2 (SOX2) and paired-like homeodomain 1 (PITX1) can activate wound healing, and is now evaluating the transcription...
10:59 AM, Aug 29, 2018  |  BC Innovations | Distillery Techniques

Other

TECHNOLOGY: Computational models A computational model based on T cell function could help predict responses to checkpoint inhibitors in cancer patients. The model, dubbed Tumor Immune Dysfunction and Exclusion (TIDE) predictor, was generated in two...
10:58 AM, Aug 29, 2018  |  BC Innovations | Distillery Techniques

Other

TECHNOLOGY: Computational models A computational method based on transcriptomic data could help predict patient response to checkpoint inhibitors. The model, called immuno-predictive score (IMPRES), involves comparing tumor expression levels of 15 pairs of immune checkpoint transcripts...
10:57 AM, Aug 29, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Antibody scaffolds Sialylation of immune complexes could enhance the response to HIV vaccines. Patients who spontaneously controlled HIV without therapy and patients who had evolved neutralizing activity against a panel of 11 HIV-1 viruses (neutralizers)...
10:57 AM, Aug 29, 2018  |  BC Innovations | Distillery Techniques

Imaging; other

TECHNOLOGY: MRI; computational models A computational model based on functional MRI and clinical presentation could predict whether unconscious brain injury patients will recover consciousness within 12 months. The model incorporates functional MRI imaging, injury etiology,...

Pages