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    E.g., 2018-02-24

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13822 items
12:49 PM, Feb 14, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Neurofibromatosis Patient sample and mouse studies suggest c-MET inhibitors could help treat neurofibromatosis type II. In neural tissue from patients, level of c-MET mRNA were higher in neurofibromatosis type II schwannomas than in unaffected nerves....
4:57 PM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cellular assays; high throughput screening A high throughput yeast-based method of antibody screening could help identify therapeutic antibodies in human blood. The method involves three steps: engineering a yeast strain with cell-surface expression of a...
4:56 PM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Addiction Mouse studies suggest inhibiting RGS20 could help treat morphine addiction. In periaqueductal gray samples from morphine-treated mice, levels of RGS20 protein were higher than in samples from vehicle-treated mice. In mice treated with intraperitoneal...
4:55 PM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Cell culture and mouse studies suggest inhibiting S. aureus AgrA or activating TRPV1 could help treat S. aureus-induced pain. In co-cultures of mouse dorsal root ganglion cells and S. aureus, knockout of S. aureus...
4:55 PM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: HIV / AIDS Mouse studies identified a prodrug of the HIV integrase inhibitor Tivicay dolutegravir that could help treat HIV infection. The prodrug consists of Tivicay modified with myristic acid for formation of hydrophobic and...
4:55 PM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Cardiovascular

INDICATION: Aneurysm Mouse studies suggest the CysLT1 inhibitor Singulair montelukast could help treat abdominal aortic aneurysm (AAA). In a mouse model of calcium chloride-induced AAA, Singulair decreased aortic dilation compared with no treatment. In a...
8:59 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Binding assays A method for unbiased detection of protein-small molecule interactions could be used to identify the protein targets of small molecules. The method involves four steps: exposing a proteome sample to a metabolite or...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Other

TECHNOLOGY: Computational models A method for designing small molecules that covalently bind conserved catalytic lysines could be used to generate selective, irreversible kinase inhibitors. The method utilizes in silico modeling of the interactions between analogs of...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A diazepine-based compound could be used to probe the role of SPPL2A in antigen-presenting cells (APCs) that drive rheumatoid arthritis, multiple sclerosis and other autoimmune diseases. Chemical synthesis, in vitro testing and cell-based...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; disease models

TECHNOLOGY: Cellular assays; 3-D models A 3-D culture system that mimics brain tissue could be used to model drug resistance in glioblastoma multiforme and screen therapies. The system involves culturing human GBM cell lines in a...

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