Publications

Show Filters

Searches all publications.

Search Fulltext

Publications

Section

Select publication to see the relevant sections.

Publication Date

    E.g., 2018-06-25
    E.g., 2018-06-25

Articles

14265 items
2:13 PM, Jun 13, 2018  |  BC Innovations | Translation in Brief

Quorum sensitivity

By engineering HEK cells with machinery to produce and secrete quorum-sensing molecules, an ETH Zurich team has developed microbe-sensing technology it believes could prevent the development of drug resistance by reducing biofilm formation and possibly...
11:26 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Other

TECHNOLOGY: Computational models A method for designing small molecules that bind two protein targets could be used to generate dual inhibitors. The method utilizes in silico docking of a library of drug-like compounds and compound fragments...
11:26 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays A microfluidics-based method for detecting tumor cells in urine could help diagnose bladder cancer. The assay involves two steps: adding patient urine samples to a microfluidics device consisting of a chamber for directional...
11:25 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts Mice expressing a COL17A1 variant could be used to screen therapies for inflammatory skin diseases. Mice with skin-specific knock-in of a COL17A1 variant lacking the NC16A domain recapitulated the skin inflammation, eczematous...
11:25 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Other Exosomes could be used to deliver peptide-conjugated nucleic acid therapies for multiple diseases. The method involves loading exosomes with therapeutic nucleic acids conjugated to a 12-amino acid peptide engineered to bind the extracellular domain...
11:25 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Cell models A method of directly reprogramming human adult T cells into neurons could be used to generate cell-based models of neurological diseases. The method involves transfecting primary human T cells with a combination...
11:25 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cellular assays A method for measuring levels of lipolysis in abdominal white adipose tissue (WAT) could help predict the risk of diabetes. The method involves incubating abdominal WAT samples separately with isoprenaline, noradrenaline and dibutyryl...
11:23 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Acute lymphoblastic leukemia (ALL); ovarian cancer; solid tumors Mouse studies suggest IL-18-secreting CAR T cells could help treat ALL, thymoma and ovarian cancer. In a xenograft mouse model of ALL, CD19-targeting CAR T cells engineered...
11:22 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Candida HEK cells engineered to synthesize and secrete bacterial AI-2 could help treat candidiasis. The cells are generated by transfecting HEK cells with two constructs: a sensor unit, based on formyl peptide receptor 1 (FPR1),...
11:21 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cancer In vitro and cell culture studies identified a quindoline-based stabilizer of the NRAS mRNA G-quadruplex region that could help treat cancer. Chemical synthesis and in vitro testing in binding and enzyme activity assays of...

Pages