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Articles

14265 items
12:22 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy MDM2-mediated inhibition of p53 could enhance the efficiency of gene insertions using CRISPR-Cas9. The modified CRISPR protocol includes treating cell culture with the p53 inhibitor MDM2, followed by administration of ribonucleoprotein complexes containing...
12:21 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs Seven SNPs on SYNJ1 could help predict outcomes in familial AD. Genome-wide association studies (GWAS) in 305 early-onset and 2,199 late-onset familial AD patients identified four SNPs in SYNJ1 associated with rapid disease onset...
12:21 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy A method utilizing click chemistry to generate injectable hydrogels containing cross-linked cells could be used in regenerative therapies. The method generates hydrogels containing cross-linked cells in three steps: metabolic incorporation of azide groups...
12:21 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Photothermal-activated nanoparticles could be used for sequential delivery of chemotherapy and photothermal therapy for cancer. The nanoparticles consist of an inner porous silica shell containing a palladium (II)-based photothermal agent which emits heat in...
12:20 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Cell models Human airway epithelium derived from organoids could be used to model pulmonary viral infections and screen therapies to treat them. The airway epithelium was generated in four steps: culturing human lung-derived cells in...
12:20 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers Levels of miR-301a in serum-derived exosomes could help diagnose and predict progression in pancreatic cancer. In serum-derived exosomes from 50 patients, miR-301a levels were higher than in serum-derived exosomes from 12 healthy...
12:19 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Patient sample, cell culture and mouse studies suggest inhibiting AMPK could help treat glioma. In tumor samples from glioblastoma and low-grade glioma patients, levels of activated AMPK were higher than in brain tissue...
12:18 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Ebola Patient sample, mouse, guinea pig and ferret studies identified three broadly neutralizing antibodies (bNAbs) against Ebola virus glycoprotein that could help treat infections by multiple Ebolavirus species and strains. Screening of neutralizing antibodies isolated...
12:14 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Inflammation; neurology

INDICATION: Shock/trauma; stroke Mouse tissue and whole animal studies suggest inhibiting TRPV4 could help treat ischemic stroke-induced or traumatic brain injury (TBI)-induced brain edema. In a mouse brain slice model of oxygen-glucose deprivation-induced ischemia, systemic TRPV4...
12:13 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cancer; melanoma Cell culture and mouse studies suggest adoptive transfer of IL-15-cultured T cells could help treat B7-H6 tumor cell ligand-positive cancers. CD8+ T cells derived from human donor blood and cultured for 12 days...

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