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5:00 PM, Apr 19, 2018  |  BC Innovations | Tools & Techniques

Structured outlook

A Cell study capturing hundreds of E. coli mRNA structures makes the case that complex, functionally relevant RNA structures are the rule, not the exception, and builds confidence that mRNAs -- once widely considered undruggable...
4:58 PM, Apr 19, 2018  |  BC Innovations | Product R&D

Automation navigation

Last year’s approvals of the first two CAR T therapies have prompted the field to get serious about industrializing manufacturing of the cells to improve reproducibility and lower costs. While stakeholders agree that automation will...
12:17 PM, Apr 19, 2018  |  BC Innovations | Emerging Company Profile

Engine power

Engine Biosciences Pte. Ltd. is marrying a CRISPR-Cas9 genetic perturbation screen with machine learning to delineate how combinations of genes contribute to disease phenotypes and thereby identify novel targets for a range of diseases. The company,...
5:46 AM, Apr 19, 2018  |  BC Innovations | Translation in Brief

One-two punch for West Nile

In a one-two punch, a group from Yale University and Hanyang University developed an intranasal therapy that treated West Nile viral infection and prevented its recurrence by promoting natural immunity in mice, effectively creating a...
10:47 AM, Apr 18, 2018  |  BC Innovations | Translation in Brief

Model combination

Certara L.P.’s latest precompetitive consortium is designed to solve the complexities of combination immuno-oncology therapy through in silico modeling. The new Immuno-oncology Simulator Consortium is using Certara’s Quantitative Systems Pharmacology (QSP) platform and preclinical and clinical...
9:05 AM, Apr 18, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample and mouse studies suggest inhibiting PDGFCC alone or in combination with estrogen receptor antagonists could help treat breast cancer. In patients, high tumor levels of PDGFCC were associated with poor...
9:04 AM, Apr 18, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting ZMYND8 could help treat breast cancer. In breast cancer patient samples, levels of ZMYND8 mRNA in primary tumors were higher than in adjacent normal...
9:03 AM, Apr 18, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting CDC25A, CDC25B and CDC25C could help treat breast cancer. In breast cancer patients, high tumor levels of CDC25A, CDC25B and CDC25C correlated with poor...
9:03 AM, Apr 18, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Chikungunya virus; Zika virus Mouse studies suggest a vaccinia virus-based vaccine expressing Zika and Chikungunya viral antigens could help prevent Zika and Chikungunya infections. The vaccine consists of seven viral antigens encoded by an attenuated...
9:02 AM, Apr 18, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes; metabolic syndrome Cell culture and mouse studies identified small molecule autophagy enhancers that could help treat metabolic syndrome and diabetes. Screening of a small molecule library in a human cell-based assay of autophagy identified...

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