Publications

Show Filters

Searches all publications.

Search Fulltext

Publications

Section

Select publication to see the relevant sections.

Publication Date

    E.g., 2018-06-24
    E.g., 2018-06-24

Articles

Pages

14265 items
6:34 PM, Jun 21, 2018  |  BC Innovations | Targets & Mechanisms

T cell balancing act

Among the improvements to next-generation CAR T cell therapies is the need to optimize the ratios of the different T cell subsets. While CD8+ T cells have grabbed most of the attention, a study from...
4:59 PM, Jun 21, 2018  |  BC Innovations | Product R&D

Tusk’s take on CD25

As companies revisit the potential of IL-2 to aid cancer immunotherapy, Tusk Therapeutics Ltd. has a new take by attacking CD25, a component of the IL-2 receptor with its own storied past. Its antibody could...
2:10 PM, Jun 21, 2018  |  BC Innovations | Translation in Brief

Liver’s killer instinct

A study in Science suggests natural killer T cells residing in the liver uniquely position the organ to reap antitumor effects from antibiotic-mediated microbiome depletion, uncovering a novel link in the microbiome-cancer relationship that highlights...
11:29 AM, Jun 21, 2018  |  BC Innovations | Emerging Company Profile

Getting past PTSD

Neurovation Labs Inc. is developing a GRIA1-targeting tracer and a small molecule therapy that could provide an objective diagnosis of PTSD and treat the underlying disease instead of just its symptoms. Post-traumatic stress disorder (PTSD) is...
9:49 AM, Jun 21, 2018  |  BC Innovations | Translation in Brief

PHIP the script

Cancers lacking key molecular signatures targeted by precision therapies are among the most challenging to treat, but a new study has identified a target, PHIP, for three of those difficult tumor types. A group led...
2:02 PM, Jun 20, 2018  |  BC Innovations | Translation in Brief

Alterations made to measure

Taking its gene editing services a step farther than other service providers that offer CRISPR editing tools and standard pre-edited cell lines, Synthego Corp. launched a portfolio of customized CRISPR-edited cell products. The new offering...
12:24 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy Complex tissue fragments incorporating MSCs and HUVECs could enhance the engraftment of transplanted tissues. The complex tissue fragments are generated by: treating select tissue samples with collagenase to generate tissue fragments; co-culturing the...
12:23 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy A four-compound cocktail could enhance the efficiency of CRISPR-based editing in pluripotent stem cells. The method involves CRISPR-based editing in pluripotent stem cells with systems based on CRISPR from Prevotella and Francisella 1...
12:23 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers Low esophageal levels of SPINK7 could help diagnose eosinophilic esophagitis. In esophageal tissue samples, SPINK7 protein and mRNA levels were lower in patients with eosinophilic esophagitis than in healthy volunteers, and the low...
12:22 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug delivery; drug platforms

TECHNOLOGY: Other; gene therapy Caffeine-sensitive cell implants could be used to deliver gene therapies for diabetes and other diseases. The implants were generated by constructing a plasmid encoding a single-domain camelid antibody that homodimerizes in the...

Pages