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14424 items
9:31 AM, Aug 15, 2018  |  BC Innovations | Translation in Brief

Not your typical vaccine

In a July paper in the Proceedings of the National Academy of Sciences, University of Mississippi Medical Center researchers and colleagues identified conserved proteins in non-typeable Haemophilius influenzae that activate T cell responses to the...
8:53 AM, Aug 15, 2018  |  BC Innovations | Emerging Company Profile

Breaking bad biofilms

Synspira LLC is developing glycopolymers against pulmonary disorders by targeting three mechanisms that exacerbate pulmonary decline: bacteria themselves, the mucus and biofilms that protect them and inflammation that leads to lasting tissue damage. Synspira spun out...
9:34 AM, Aug 14, 2018  |  BC Innovations | Translation in Brief

Primate predictions

A team at Illumina Inc. (NASDAQ:ILMN) has developed an AI algorithm that will help identify pathogenic mutations from genome sequencing analyses by including non-human primate data in the training data set, and the approach could...
8:00 PM, Aug 09, 2018  |  BC Innovations | Targets & Mechanisms

Getting to function

A new target for sarcopenia that increases muscle function directly, in addition to adding muscle mass, could help address calls from patients and regulators to make functional recovery central to drug development in the indication. Sarcopenia...
6:37 PM, Aug 09, 2018  |  BC Innovations | Finance

Super-sized ambitions

A trend toward super-sized initial financings is attracting a new set of deep-pocketed investors to the early stage space. These new players are making earlier commitments with hopes of guaranteeing larger ownership positions at an...
12:42 PM, Aug 09, 2018  |  BC Innovations | Translation in Brief

Buggy Bug World

A data dive into the TwinsUK registry based at King’s College London has revealed new associations between gut microbiota and disease, including some outside the usual suspects, like urinary incontinence. The study found not just...
10:02 AM, Aug 09, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cellular assays; high throughput screening A high throughput, CRISPR interference (CRISPRi)-based method of mapping genetic interactions could help identify new drug targets for cancer and genetic disorders. The method involves: selecting sgRNAs against genes identified...
10:00 AM, Aug 09, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy A biomanufacturing method could enable ex vivo production of human platelets to treat thrombocytopenia and other hematologic indications. In human induced pluripotent stem (iPS) cell-derived megakaryocyte cell lines cultured in shaking flasks,...
10:00 AM, Aug 09, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; other

TECHNOLOGY: Diagnostic assays; computational models An algorithm-based method that predicts clinical response to synthetically lethal mutation-drug pairs could help match cancer patients to therapies and stratify patients for clinical trials. The method, dubbed identification of clinically...
5:38 PM, Aug 08, 2018  |  BC Innovations | Translation in Brief

Identifying the ubiquitinators

A team at University of Dundee and Newcastle University has developed a mass spectrometry-based screening platform to identify ubiquitin ligases and compounds that modulate them. The approach uses the uptake of ubiquitin by enzymes rather...