Featured Story BioCentury & Getty ImagesRise of the first-time biotech CEO

A shortage of management talent is creating opportunities for more first-time CEOs to experience the top job. While this could open the door to more diverse executive teams, there’s no sign of that ...

Featured Story BioCentury & Getty ImagesPharma spinouts: a snapshot of where and how pharmas spin out their assets

The handoff of innovation to academia is all but complete, with universities and other academic institutions accounting for the origin of about 75% of new companies formed in the last three years. But ...

Targets & Mechanisms BioCentury & Getty ImagesControlling T cells via epigenetics

An international academic team has discovered an epigenetic pathway that regulates CD4 + T cell differentiation and activity, and could yield new therapeutic targets for autoimmunity. As drug ...

Tools & Techniques BioCentury & Getty ImagesEditing bacterial resistance via gene drives

In a new take on combating antimicrobial resistance, a UCSD team developed a gene drive system that could reduce resistance more efficiently than conventional CRISPR-based editing. CRISPR-based gene ...

Emerging Company Profile BioCentury & Getty ImagesTriplet debuts with $59M, therapies for repeat expansion disorders

When new research emerged last year pegging the DNA damage response pathway as a main driver of repeat expansion disorders, rather than the genetic mutations themselves, Atlas Venture co-founded and ...

Distillery Therapeutics Inhibiting tankyrase to treat osteoarthritis and regenerate cartilage

DISEASE CATEGORY: Autoimmune disease INDICATION: Osteoarthritis Combined TNKS and TNKS2 inhibition could treat osteoarthritis, which features progressive cartilage degeneration, and Read the full 190 ...

Distillery Therapeutics SLC5A12 inhibition for rheumatoid arthritis

DISEASE CATEGORY: Autoimmune disease INDICATION: Rheumatoid arthritis (RA) Inhibiting the lactate transporter SLC5A12 could treat RA. In Read the full 154 word article

Distillery Therapeutics Combined inhibition of CDK12 and CDK13 for TNBC

DISEASE CATEGORY: Cancer INDICATION: Breast cancer A Moffitt Cancer Center and Research Institute team showed that dual inhibition of Read the full 179 word article

Distillery Therapeutics The proteasome-regulating kinase DYRK2 as a target in breast cancer and multiple myeloma

DISEASE CATEGORY: Cancer INDICATION: Breast cancer; multiple myeloma (MM) Inhibiting the proteasome-regulating kinase DYRK2 could treat breast cancer and MM. In patients with Read the full 216 word ...

Distillery Therapeutics Raising PDLIM2 expression to treat lung cancer

DISEASE CATEGORY: Cancer INDICATION: Lung cancer Promoting the expression of PDLIM2, which has been proposed Read the full 130 word article

Distillery Therapeutics An inhibitor of viral latency for imaging, treating EBV-associated cancers

DISEASE CATEGORY: Cancer INDICATION: Nasopharyngeal cancer; lymphoma A peptide-based compound that inhibits EBNA1, which promotes Epstein-Barr virus latency, could be used to image and treat Read the ...

Distillery Therapeutics Combined inhibition of EIF4A1 and glutaminase for pancreatic cancer

DISEASE CATEGORY: Cancer INDICATION: Pancreatic cancer Inhibiting the translation initiator EIF4A1 and the glutamine metabolism enzyme GLS could treat Read the full 175 word article

Distillery Therapeutics CXCR2 inhibition could overcome androgen receptor antagonist resistance in prostate cancer

DISEASE CATEGORY: Cancer INDICATION: Prostate cancer Inhibiting CXCR2 could treat androgen receptor antagonist-resistant prostate cancer. Knockout of CXCR2, which is Read the full 189 word article

Distillery Therapeutics HDAC9 identified as target in atherosclerosis

DISEASE CATEGORY: Cardiovascular INDICATION: Atherosclerosis Inhibiting HDAC9 could treat atherosclerosis by reducing vascular calcification, one of the disease's Read the full 166 word article

Distillery Therapeutics Depleting platelets of inhibiting SOCS3 for atherosclerosis

DISEASE CATEGORY: Cardiovascular INDICATION: Atherosclerosis Platelet depletion or inhibition of SOCS3, a platelet-induced regulator of macrophage polarization, Read the full 157 word article

Distillery Therapeutics Skin grafts based on CRISPR-edited iPS cells to treat epidermolysis bullosa

DISEASE CATEGORY: Dermatology INDICATION: Blistering disorder Skin grafts based on CRISPR-edited induced pluripotent stem (iPS) cells could treat Read the full 163 word article

Distillery Therapeutics Gut microbe metabolites as treatments for iron overload

DISEASE CATEGORY: Hematology INDICATION: Iron overload The microbial metabolites diaminopropane and reuterin could treat iron overload by inhibiting HIF2A, which Read the full 181 word article

Distillery Therapeutics Benzoxaborole-based CPSF3 inhibitor to treat infections

DISEASE CATEGORY: Infectious disease INDICATION: Cryptosporidium Inhibiting the Cryptosporidium CPSF3 homolog with AN3661 could treat infections by the parasite, which can be lethal Read the full 219 ...

Distillery Therapeutics miR-130b mimics to treat sepsis

DISEASE CATEGORY: Infectious disease INDICATION: Sepsis The microRNA miR-130b could treat sepsis by inhibiting CIRP, a Read the full 149 word article

Distillery Therapeutics Promoting calcium channel signaling in muscle to treat age-related atrophy

DISEASE CATEGORY: Musculoskeletal INDICATION: Muscular atrophy Increasing signaling through the embryonic isoform of the skeletal Read the full 135 word article

Distillery Therapeutics CAPN3 gene therapy for limb-girdle muscular dystrophy type 2A

DISEASE CATEGORY: Musculoskeletal INDICATION: Muscular dystrophy An adeno-associated viral vector deliverying CAPN3, a calcium-dependent protease expressed at Read the full 154 word article

Distillery Therapeutics Inhibiting the EIF4G1-EIF4E interaction to treat autism

DISEASE CATEGORY: Neurology INDICATION: Autism Disrupting the EIF4G1-EIF4E interaction could treat autism, a disorder characterized by Read the full 143 word article

Distillery Therapeutics Targeting the integrated stress response to treat Down syndrome

DISEASE CATEGORY: Neurology INDICATION: Cognitive dysfunction Suppressing the integrated stress response (ISR) by activating EIF2B or inhibiting EIF2AK2 could treat Down Read the full 190 word article

Distillery Therapeutics Negative allosteric modulators of glutamate receptor subtypes mGluR2 and mGluR3

DISEASE CATEGORY: Neurology INDICATION: Depression Negative allosteric modulators of the glutamate receptor subtypes mGluR2 and mGluR3 could Read the full 151 word article

Distillery Therapeutics ELK1 overexpression for Huntington disease

DISEASE CATEGORY: Neurology INDICATION: Huntington disease (HD) Promoting expression of the transcription factor ELK1 could Read the full 135 word article

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