Atlas Insights: Targetable directions in Parkinson’s disease

Single‑cell and multi‑omic Parkinson’s disease atlases are turning scattered genetic and immunological clues into insights that could serve as druggable cell states and pathways.

In the classic Braak staging scheme, Lewy body pathology appears first in lower brainstem nuclei, then ascends through midbrain structures like the substantia nigra, and only later involves limbic and neocortical regions, meaning different brain areas sit at different points along the Parkinson’s trajectory at any given time. ...