Human neural models get closer to CNS disease

New human cell models are giving researchers access to three dimensions of CNS disease that earlier iPSC systems struggled to capture: circuit dysfunction, temporal progression, and selective vulnerability.

For much of the induced pluripotent stem cell (iPSC) era, human cell models have mostly meant dissociated neurons, which are rich in omics data but poor in the high-order features that make brain diseases so challenging to treat...