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Combined inhibition of CDK12 and CDK13 for TNBC

DISEASE CATEGORY: Cancer INDICATION: Breast cancer A Moffitt Cancer Center and Research Institute team showed that dual inhibition of CDK12 and CDK13 could treat triple-negative breast cancer (TNBC). In four human TNBC cell lines, an...

HDAC9 identified as target in atherosclerosis

DISEASE CATEGORY: Cardiovascular INDICATION: Atherosclerosis Inhibiting HDAC9 could treat atherosclerosis by reducing vascular calcification, one of the disease's hallmarks. Six SNPs for which HDAC9 is the nearest gene were associated with abdominal aortic calcification in...

Engineered ECM scaffolds to facilitate muscle, nerve and vascular regeneration

DISEASE CATEGORY: Transplant INDICATION: Tissue replacement Engineered polymer-based extracellular matrix (ECM) scaffolds could improve tissue regeneration after transplantation or injury. The method involves fabricating membranous or tubular templates out of synthetic polymers, implanting the templates...

Small molecule STAT3 degrader for leukemia, lymphoma

DISEASE CATEGORY: Cancer INDICATION: Leukemia, lymphoma A University of Michigan team led by Oncopia Therapeutics LLC co-founder Shaomeng Wang has designed a proteolysis-inducing degrader of STAT3 that could treat leukemia and lymphoma. The STAT3 degrader...

Dopamine receptor agonism for pulmonary fibrosis, liver fibrosis

DISEASE CATEGORY: Pulmonary; hepatic INDICATION: Pulmonary fibrosis; liver fibrosis Agonism of the dopamine receptor DRD1 could treat pulmonary and liver fibrosis. In cultures of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis (IPF), a...

Bacteriophages for alcoholic liver disease

DISEASE CATEGORY: Liver disease INDICATION: Alcoholic hepatitis Targeting a strain of microbiome member Enterococcus faecalis that expresses the exotoxin cytolysin could treat alcohic hepatitis. Seventy-five patients with alcoholic hepatitis had higher fecal counts of E....

Epigenetic protein YTHDF1 identified as NSCLC target

DISEASE CATEGORY: Cancer INDICATION: Lung cancer Inhibiting YTHDF1, a protein that controls translation of several cell cycle regulators, could treat non-small cell lung cancer (NSCLC). YTHDF1 protein and mRNA levels were higher in tumor tissue...

Entinostat-derived LSD1 and HDAC dual inhibitor for pediatric glioma

DISEASE CATEGORY: Cancer INDICATION: Brain cancer An HDAC and LSD1 inhibitor could treat diffuse intrinsic pontine glioma, a subtype of pediatric brain cancer. A dual HDAC and LSD1 inhibitor tool compound, derived from the HDAC...

The flavonoid prunin could treat enterovirus A71 infection

DISEASE CATEGORY: Infectious disease INDICATION: Enterovirus The plant pigment prunin could treat infections by enterovirus A71 strains that cause hand, foot and mouth disease, in which a subset of patients develop paralysis. In cell-based infection...

PGAM1 inhibition to treat pancreatic cancer

DISEASE CATEGORY: Cancer INDICATION: Pancreatic cancer Inhibiting the glycolysis enzyme PGAM1 could treat pancreatic cancer including pancreatic ductal adenocarcinoma (PDAC). In 50 PDAC patients, PGAM1 protein levels were higher in tumor tissue than in adjacent...

Drug-loaded lipid nanoparticles targeting tumor-associated myeloid cells for glioma

DISEASE CATEGORY: Cancer INDICATION: Brain cancer Targeting immunosuppressive tumor-associated myeloid cells (TAMCs) with drug-loaded anti-PD-L1 lipid nanoparticles could treat glioma, an indication in which TAMCs contribute up to 50% of the tumor mass. The nanoparticles,...

AGR2 and LYPD3 as breast cancer targets

DISEASE CATEGORY: Cancer INDICATION: Breast cancer Inhibiting the membrane receptor LYPD3 or its ligand AGR2 could treat endocrine therapy-resistant breast cancer. In patients with estrogen receptor-positive breast cancer, higher tumor levels of LYPD3 protein were...

A vaccine made of red blood cell and tumor cell membranes plus checkpoint blockade for breast cancer, melanoma

DISEASE CATEGORY: Cancer INDICATION: Breast cancer; melanoma Personalized vaccines derived from red blood cells and tumor cells could synergize with checkpoint inhibitors to treat breast cancer and melanoma. The vaccines are created by fusing hemoglobin-depleted...

Combining Arava with HIF1A inhibition to treat RA

DISEASE CATEGORY: Autoimmune disease INDICATION: Rheumatoid arthritis (RA) Inhibiting HIF1A could enhance the efficacy of Arava leflunomide for RA-associated bone erosion in patients with high C-reactive protein levels. In a rat model of RA, Arava...

Reducing ER stress through USP14 inhibition could treat diabetes

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Diabetes Targeting USP14 could treat Type II diabetes by reducing the effects of endoplasmic reticulum stress, which has been implicated in the disease’s pathogenesis. In lean mice, the ER stress inducer...