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A single-shot, measles-vectored vaccine for Lassa virus

DISEASE CATEGORY: Infectious disease INDICATION: Viral hemorrhagic fever Vaccination with a measles virus vector expressing Lassa virus glycoprotein and nucleoprotein could prevent Lassa virus infection. In monkeys challenged with one of three Lassa virus strains, pretreatment...

A CD81-targeting mAb for solid tumors

DISEASE CATEGORY: Cancer INDICATION: Breast cancer; lung cancer A mAb targeting the tetraspanin CD81 could treat breast and lung cancers. In human triple-negative breast cancer (TNBC) and lung cancer cell lines, an IgG2a anti-CD81 mAb...

An optimized version of the discontinued EGFRvIII-targeting GBM vaccine candidate Rintega

DISEASE CATEGORY: Cancer INDICATION: Brain cancer Introducing a G6Y amino acid substitution that enhances its proteasomal cleavage could improve the efficacy of the discontinued EGFRvIII-targeting therapeutic...

Adding an IL-10 fusion protein to T cell therapy or immune checkpoint blockade in solid tumors

DISEASE CATEGORY: Cancer INDICATION: Colorectal cancer; melanoma A recombinant IL-10 fusion protein could enhance the efficacy of adoptive T cell transfer and immune checkpoint blockade in solid tumors. In a mouse model of melanoma treated...

C1QBP-targeting CAR T cell therapy for gliomas

DISEASE CATEGORY: Cancer INDICATION: Brain cancer CAR T cells against the complement subcomponent C1QBP could treat gliomas, including glioblastoma multiforme (GBM). In patients, levels of C1QBP mRNA were higher in glioma samples than in non-tumor tissue, and...

SHH, YAP1 inhibition for genetic, acquired heterotopic ossification

DISEASE CATEGORY: Musculoskeletal INDICATION: Bone repair Targeting the hedgehog ligand SHH or YAP1, which drives SHH expression, could treat both genetic and acquired forms of heterotopic ossification, an ectopic formation of bone in extraskeletal tissues....

ROS regulator PHB identified as glioma target

DISEASE CATEGORY: Cancer INDICATION: Brain cancer A team from China’s Academy of Military Medical Sciences showed that targeting the mitochondrial reactive oxygen species (ROS) regulator PHB could treat gliomas. Levels of PHB protein were higher in...

A modified CRISPR adenine base editor with a minimal PAM requirement for DMD

DISEASE CATEGORY: Musculoskeletal INDICATION: Muscular dystrophy Ohio State University researchers showed that a modified CRISPR adenine base editor for Duchenne muscular dystrophy (DMD) could overcome challenges posed by the protospacer adjacent motif (PAM) requirements, large...

Natural lipopeptide antibiotics for Acinetobacter infections

DISEASE CATEGORY: Infectious disease INDICATION: Gram-negative bacterial infection University of Utah researchers identified two lipopeptide antibiotics derived from a marine shipworm symbiont that could treat infections by Acinetobacter baumannii and other Gram-negative bacteria. The two...

Combining CD51-TGFβ axis inhibition with NK cell therapy for glioblastoma

DISEASE CATEGORY: Cancer INDICATION: Brain cancer Targeting TGFβ activation mediated via the integrin CD51 could improve NK cell therapy in glioblastoma. Tumor-infiltrating NK cells from glioblastoma patients showed increased expression of genes involved in the...

Targeting SIGLEC7, SIGLEC9 in solid tumors

DISEASE CATEGORY: Cancer INDICATION: Colorectal cancer; melanoma Targeting the myeloid receptors SIGLEC7 and SIGLEC9 could treat colorectal cancer and melanoma. In a mouse model of melanoma with lung metastases, knockout of the mouse homolog of SIGLEC9...

Macrophage-reprogramming engineered exosomes for arthritis

DISEASE CATEGORY: Autoimmune disease INDICATION: Rheumatoid arthritis (RA) Engineered mesenchymal stem cell-derived exosomes designed to target and reprogram macrophages could treat RA. The exosomes naturally express the miRNAs MIRLET7B5P and miR-24-3p, which contribute to M1 to...

Targeting SDCBP in metastatic breast cancer

DISEASE CATEGORY: Cancer INDICATION: Breast cancer Inhibiting the adapter protein SDCBP could treat metastatic breast cancer. In mice, the SDCBP inhibitor PDZ1i reduced primary tumor growth by 40% and decreased lung metastases. InVaMet Therapeutics Inc. has...

An engineered ACE2 fusion protein as a COVID-19 therapy

DISEASE CATEGORY: Infectious disease INDICATION: Coronavirus disease (COVID-19) An engineered soluble ACE2 fusion protein that neutralizes SARS-CoV-2 by acting as a decoy receptor could treat COVID-19. Mutagenesis of human ACE2 followed by screening for binding to...

A patient-derived CSP-targeting mAb to treat malaria

DISEASE CATEGORY: Infectious disease INDICATION: Malaria Researchers at NIH identified a mAb targeting CSP, the dominant protein on the Plasmodium falciparum sporozoite surface, that could treat malaria. Screening of IgA antibodies from two malaria-resistant Malian individuals who were P. falciparum...