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 | 
Jan 29, 2007
 |  BioCentury  |  Tools & Techniques

Unmasking gp120

Although more than 50 different preventive HIV vaccine candidates have entered clinical trials since 1987, none has been approved. A newly discovered region of HIV gp120 could revive interest in what was one of the original vaccine targets, because it is exposed, semi-conserved and highly sensitive to monoclonal antibodies.

"Previous vaccines have used one or two gp120 sequences," said Abraham Pinter, head of the laboratory of retroviral biology at the...

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