2:45 PM
May 12, 2017
 |  BioCentury  |  Strategy

Vertical vision

How Shire’s Parion deal adds to its ophthalmics pipeline

Shire plc’s deal with Parion Sciences Inc. is a step toward building vertically in ophthalmics, much like it has done in hereditary angioedema and hemophilia.

On May 1, Shire gained exclusive, worldwide rights to P-321 ophthalmic solution, an epithelial sodium channel (ENaC) inhibitor in development to treat dry eye disease.

The candidate is Shire’s second for dry eye; it launched Xiidra lifitegrast in September. Shire gained that drug, then in Phase III testing, via the 2013 acquisition of SARcode Bioscience Inc.

Shire hasn’t decided yet how P-321 will slot alongside Xiidra, but it believes having another molecule in dry eye with a novel MOA will be complementary.

“If you want to be a market leader in any therapeutic area, you need to have different treatment options for different patients.”

Perry Sternberg, Shire

According to BioCentury’s BCIQ online database, P-321 is the only ENaC inhibitor in the clinic for dry eye.

ENaC is a protein found on the surface of the eye and many other tissues. On the surface of the eye, it regulates the intake of sodium...

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