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Aug 16, 2010
 |  BioCentury  |  Product Development

New tack on tau

Merck, Alectos partner to develop new way to tackle tau in Alzheimer's

Merck & Co. Inc. has signed on to a novel way of tackling tau, a key component of the neurofibrillary tangles in Alzheimer's disease. Last week the pharma unveiled a co-development deal with Alectos Therapeutics Inc., which is developing modulators of O-linked N-acetylglucosaminidase, an enzyme that has shown potential for blocking hyperphosphorylation of tau. The deal could be worth up to $289 million.

Microtubule-associated protein-t (MAPT; tau; FTDP-17) stabilizes axonal microtubules that normally facilitate intracellular neuronal trafficking. In neurodegenerative diseases, it undergoes aberrant phosphorylation and loses its ability to maintain the structures...

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