Computing brain entry

How 1st Biotherapeutics is applying computational tools to CNS drug discovery

1st Biotherapeutics Inc. aims to develop a pipeline of first- or best-in-class molecules for CNS diseases by using computational tools to achieve better blood-brain barrier penetration and PK properties than marketed drugs against the same targets. Lead candidate 1ST-102 is a preclinical ABL proto-oncogene 1 non-receptor tyrosine kinase (c-ABL; ABL; ABL1) inhibitor in development for Parkinson’s disease.

CEO Jamie Jae Eun Kim told BioCentury she launched 1st Biotherapeutics in 2016 after assembling a suite of computational tools

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