BioStratum other research news

University researchers collaborating with BioStratum published identification of drug candidates to prevent complications of high blood glucose in diabetics. As reported in the Journal of Biological Chemistry, the compounds block the non-enzymatic glycation of proteins, nucleic acids, and lipids through the formation of an intermediate molecule called the Amadori intermediate. The compounds stop the conversion of the Amadori intermediates into advanced glycation end-products (AGEs). Pyridoxamine, a derivative of vitamin B6, was active in the assay, and also has been found to block development of kidney damage in diabetic animal models, the company said. ...