Actelion preclinical data

Researchers at Wayne State University School of Medicine reported data from rats showing that IV clazosentan administered 2 and 24 hours after TBI reduced the extent of injury-induced hypoperfusion as measured by arterial spin labeling MRI and improved behavioral outcomes as measured by a radial arm maze-spatial learning task vs. controls. Data will be presented at the American Academy of Neurology meeting in New Orleans in April. Clazosentan is an endothelin A receptor antagonist. ...