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Nov 05, 2012
 |  BC Week In Review  |  Clinical News  |  Clinical Status

Tivantinib: Phase III discontinued

ArQule and Asian partner Kyowa discontinued the double-blind, Asian Phase III ATTENTION trial of tivantinib based on a recommendation by the trial's safety committee. ATTENTION was comparing tivantinib plus Tarceva erlotinib vs. Tarceva alone in 460 EGFR wild-type patients with locally advanced or metastatic, non-squamous NSCLC who received 1-2 prior systemic cancer therapies. In August, the partners suspended enrollment in the trial following an imbalance of interstitial lung disease between treatment arms. ArQule said data from ATTENTION are expected...

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