9:47 AM
Oct 26, 2018
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Latest immuno-oncology monotherapy data continue to cast doubt on combo strategies

New data for next generation immuno-oncology agents add to the debate of whether and how agents that show no efficacy as monotherapies in Phase I trials should be advanced to later stage combination trials. Merck & Co. Inc. (NYSE:MRK) and Eli Lilly and Co. (NYSE:LLY) each presented data at the European Society for Medical Oncology meeting in Munich showing that MK-1454 and pegilodecakin (AM0010) led to no responses as monotherapies across several indications, despite showing some efficacy in combination with chemotherapy or checkpoint inhibitors.

Merck reported that MK-1454 as monotherapy led to no responses in 20 evaluable patients in a Phase I trial to treat advanced solid tumors or lymphomas. The disease control rate in the monotherapy arm for the transmembrane protein 173...

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