Dirame propiram: Phase III

Roberts said that preliminary results of its 350-patient Phase III trial of Dirame to treat post-operative dental pain showed statistically significant analgesic effects at doses of 50 mg and above. Patients who had 2 or more third molars extracted received either placebo, 100 mg of Ortho-McNeil's Ultram tramadol opioid analgesic or 25, 50, 100 or 150 mg of Dirame. Dirame produced significant benefits compared to Ultram or placebo on the primary end point of pain intensity differences from baseline over several hours.

It is common for opioid receptor modulators to be both agonists and antagonists because they affect multiple receptors. Dirame is predominantly an agonist (analgesic) but has some antagonist properties that reduce neurological side effects. ...