ARTICLE | Translation in Brief
PK prediction help
A large, publicly available data set for predicting PK from structure for IV drugs
September 26, 2018 10:39 PM UTC
In an August Drug Metabolism and Disposition study, a team from Alkermes plc (NASDAQ:ALKS), Pfizer Inc. (NYSE:PFE) and Biogen Inc. (NASDAQ:BIIB) assembled PK and physicochemical properties for over a thousand IV-delivered small molecules into a data set that could power algorithms that predict PK profiles based on chemical structure. The data are available online as a public resource.
According to author Franco Lombardo, the results meet the team’s perceived need for a large data set of standardized information for IV small molecules, and the data set is the largest publicly available set of its kind. Lombardo is senior director, drug metabolism pharmacokinetics and bioanalysis at Alkermes...