11:52 AM
Oct 05, 2017
 |  BC Innovations  |  Translation in Brief

SSRIs' first responders

How cholecystokinin neurons initiate SSRI acute response

Researchers at The Rockefeller University have identified a role for CCK-expressing neurons in initiating responses to SSRIs for depression and manipulated the neurons to recapitulate the drugs' effects. The findings could lead to faster-acting antidepressants -- if the cells can be selectively targeted.

Serotonin reuptake inhibitors (SSRIs) are commonly used to treat major depressive disorder (MDD) are but latency is a problem: it can take weeks or months for a patient to fully response. Additionally, which of the 14 serotonin receptors and various neuronal cell types mediate SSRI responses are not well understood.

Previous studies by other groups have identified the dentate gyrus as a major target of serotonergic innervation. In the dentate gyrus, interneurons that express cholecystokinin (CCK) -- a hormone associated with cognitive processes, motivation and emotions -- are innervated by serotonergic cells projecting from the raphe nucleus. The connection is thought to be the primary target of SSRIs and responsible...

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