12:21 PM
Jul 13, 2017
 |  BC Innovations  |  Translation in Brief

Mind over matter

Regulating weight gain via CADM1; a new target in the gut-brain axis

In the latest link between the GI tract and the CNS, a team from the Max Delbrück Center for Molecular Medicine has identified the synaptic organizers CADM1 and CADM2 as targets in the gut-brain axis that could be inhibited to treat obesity.

The gut-brain axis involves bidirectional signaling between the CNS and the peripheral enteric system. A range of targets have been identified, including peptide tyrosine-tyrosine (PYY), neuropeptide Y (NPY), cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), and in the last few years the microbiome has been recognized as a major player involved in regulating the whole system.

Now, a group led by Matthew Poy -- a faculty member at...

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