PEGylation once removed

PEG-based excipient improves shelf life, in vivo stability of biologics

Scientists at the Massachusetts Institute of Technology (MIT) have figured out how to use PEGylation, a covalent modification, to create a non-covalent excipient that not only extends the shelf-life of biologics but boosts their in vivo stability.

Excipients used to formulate drugs work through reversible, non-covalent interactions with a drug in solution to increase its solubility and prevent aggregation, without changing the compound’s therapeutic activity. But these excipients only increase

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