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Cutting the cancer fat

A Nimbus-designed compound starves tumors of fatty acids

Nimbus Therapeutics LLC has shown one of its computationally designed acetyl-Coenzyme A carboxylase (ACC; ACAC) inhibitors, dubbed ND-646, can block the fatty acid synthesis that fuels growth of lung tumors, and has developed a biomarker of the compound's activity.

The molecule is among the suite of ACC inhibitors Gilead Sciences Inc. (NASDAQ:GILD) obtained in April when it acquired Nimbus' subsidiary, Nimbus Apollo. Last week, Gilead awarded Nimbus a $200 million

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