Pathways emerging from ASH
An analysis of emerging targets at ASH by mechanism
A survey of the emerging molecular targets at this year’s American Society of Hematology conference indicates that while harnessing the immune system to treat cancer remains a dominant interest, processes for tuning protein levels -- from epigenetics and transcription, to translation and protein degradation -- are garnering attention.
BioCentury defines emerging targets as those with low to no mentions one year that show a marked increase the next. Specifically, the count includes targets mentioned in two or fewer abstracts in ASH2016 that at least tripled in ASH2017, or that were absent last year and were mentioned in at least four abstracts at ASH2017. Grouping the targets by mechanism provides a