Broader is better
A team from the Crucell Vaccine Institute and The Scripps Research Institute has identified a trio of neutralizing human mAbs that protect mice from challenge with influenza viruses, including one mAb that protects against both A and B strains.1 Crucell N.V., first plans to develop the antibodies to treat influenza-infected individuals and in the long run could use the antibody against A and B strains as a guide for developing a universal influenza vaccine.
Despite the success of prophylactic vaccines, seasonal influenza epidemics-either by the A or B strain-still cause morbidity and mortality every year. Influenza A viruses cause seasonal flu as well as influenza pandemics and are associated with more severe clinical disease. Influenza B viruses are the cause of seasonal epidemics every two to four years.2
The seasonal trivalent inactivated influenza vaccine attempts to induce protection by including two influenza A subtypes and one influenza B lineage. However, seasonal influenza vaccine mismatches