BioCentury
ARTICLE | Targets & Mechanisms

Targeting T cell metabolism

March 3, 2011 8:00 AM UTC

Researchers at the University of Michigan have shown that modulating ATP synthase activity can selectively kill alloreactive T cells and arrestgraft-versus-host disease.1 Lycera Corp.has licensed the findings, which may provide a new indication for the small molecule partial inhibitors ofATP synthase that the company plans to advance into the clinic this year.

The findings also suggest that targeting cellular metabolism may be a viable therapeutic strategy to treat other immune diseases...