Multiple myeloma partners

The Institute of Cancer Research and Cancer Research Technology Ltd. are collaborating with Janssen Research & Development of Johnson & Johnson to modulate the unfolded protein response in multiple myeloma. Although no particulars have been disclosed by the partners, previous results from the U.K. team have suggested the kinase domain of IRE1 as a potential target in the pathway.

CRT is the commercial arm of Cancer Research UK (CRUK), a cancer charity that funds research, including at the ICR.

Standard of care for multiple myeloma (MM) includes the immunomodulatory drugs Thalomid thalidomide and Revlimid lenalidomide from Celgene Corp. and the proteasome inhibitor Velcade bortezomib

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