1:04 PM
Feb 07, 2019
 |  BC Innovations  |  Emerging Company Profile

Tara’s beating heart

How Tara’s heart-on-a-chip weeds out cardiac toxicity

Tara Biosystems Inc. is using its heart-on-a-chip platform to uncover cardiac toxicity signals in drug candidates for biopharmas as it ventures into new drug discovery.

Tara’s core technology is a 3-D cardiomyocyte culture system that mimics the electrophysiology and contractile force properties of a human ventricle.

The cardiac muscle cells are derived from induced pluripotent stem (iPS) cells and are suspended by polymer-based wires. Contraction of the cells exerts a force on the wire that can be measured, while other parameters are measured using electrophysiology.

CEO Misti Ushio said Tara’s in vitro heart tissue has a positive force frequency relationship and only beats in response to a signal, mimicking human heart cells. She said the tissue’s electrophysiology parameters, such as the resting membrane potential of the...

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