Stress relief for neurons

How Aquinnah is preventing stress granule formation to slow the progression of neurodegenerative disease

Aquinnah Pharmaceuticals is developing disease-modifying therapies for amyotrophic lateral sclerosis and Alzheimer’s disease by inhibiting the formation of stress granules that promote protein aggregation in neurons.

Stress granules are protein-RNA complexes assembled by RNA-binding proteins that form transiently in neurons in response to stress, sequestering non-essential RNA so the cell can focus on transcription of cytoprotective proteins at the expense of normal neuronal

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