1:18 PM
 | 
Dec 06, 2017
 |  BC Innovations  |  Emerging Company Profile

Building up nerve

How AxoSim is using its nerve-on-a-chip to screen compounds, model disease

AxoSim Technologies LLC has developed a 3-D human nerve-on-a-chip platform to recapitulate the in vivo organization of nerve bundles with greater fidelity to human systems than competitor models. The service provider is positioning its system both for preclinical neurotoxicity testing and modeling of diseases that affect axon tracts.

According to CEO Lowry Curley, the platform should be particularly useful for modeling peripheral neuropathy, demyelinating diseases like multiple sclerosis and certain neurodegenerative disorders, such as amyotrophic lateral sclerosis.

He said AxoSim has a partnership with an undisclosed pharma to develop an ALS model, and is working internally on an MS model that is at the proof-of-concept stage.

Although other organ-on-chips companies have created 3-D models of neural tissue, most produce tangled masses of cells and axons rather than orderly arrangements of cell bodies that send out nerve bundles in a specified direction.

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