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Jul 23, 2015
 |  BC Innovations  |  Emerging Company Profile

Metastasis in 3D

How Ixchel's 3D tissue model mimics metastasis for screening cancer therapies

Current in vivo and in vitro models for testing cancer therapeutics don't accurately model the progression of metastasis, which limits their ability to predict efficacy in patients. Ixchel Scientific's PD-3D system is a cell-based 3D model that mimics the spread of cancer in human tissues, and aims to predict the clinical success of cancer therapies more reliably than other models.

CEO Julia Kirshner and CTO Mukti Parikh developed the system in Kirshner's lab at Purdue University and designed it with two key features: a 3D structure that maintains the architecture of the tissue; and the ability to model metastatic processes that occur in human tissues.

PD-3D mimics a primary tumor by embedding cancer cell lines or patient-derived tumor cells into a well of Matrigel and overlaying the well with epithelial cell growth medium. A second, larger well containing...

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