Neurology

Mouse studies suggest the selective GABA re-uptake inhibitor tiagabine could help treat neonatal hypoxic brain injury. In a neonatal mouse model of hypoxia-induced brain injury, tiagabine decreased the percentage of missteps, a measure of motor performance, compared with vehicle, and decreased defects in Purkinje cell firing frequency in the cerebellar cortex compared with no treatment. Next steps include testing the chemogenetic activation of GABAergic Purkinje cells in models of neonatal hypoxic brain injury...