8:43 AM
 | 
Sep 27, 2018
 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Multiple myeloma (MM)

Patient sample, cell culture and mouse studies suggest antagonizing AHR could help treat MM. In patients, high tumor levels of AHR correlated with poor survival. In multiple Velcade bortezomib-resistant and -sensitive human MM cell lines, clofazimine, which antagonizes AHR, increased cell death compared with vehicle, and in the Velcade-sensitive cell lines,...

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