11:06 AM
May 15, 2018
 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Tuberculosis

Mouse studies suggest a fusion protein-based vaccine plus a STING-activating cyclic dinucleotide (CDN) adjuvant could help prevent tuberculosis (TB). The fusion protein consists of five Mycobacterium tuberculosis antigens: fbpB, esxA, hrp1, rpfD and Rv1733c. In a mouse challenge model of TB, subcutaneous immunization with the fusion protein plus STING-activating cyclic diguanylate (CDG) decreased colony-forming units (CFUs)...

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