12:14 PM
 | 
Aug 22, 2017
 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer

Patient sample, cell culture and mouse studies suggest inhibiting MCL1 could help treat triple-negative breast cancer (TNBC) and HER2-amplified breast cancer. In breast cancer patient samples, levels of MCL1 were higher in TNBC and HER2-amplified tumors than in estrogen receptor 1 (ESR1)-positive tumors. In two human TNBC cell lines and a human HER2-amplified breast cancer cell line, a MCL1...

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