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 | 
Jun 02, 2016
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: P. falciparum dihydroorotate dehydrogenase (PfDHODH); P. vivax dihydroorotate dehydrogenase (PvDHODH)

Infectious disease

INDICATION: Malaria

In vitro and mouse studies identified triazolopyrimidine-based inhibitors of PfDHODH and PvDHODH that could help treat malaria. Chemical synthesis and in vitro testing of triazolopyrimidine analogs identified three compounds that bound...

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