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 | 
May 21, 2015
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Interleukin-1 (IL-1) β; IL-1 receptor; purinergic receptor P2X ligand-gated ion channel 7 (P2RX7; P2X7)

Ophthalmic disease

INDICATION: Age-related macular degeneration (AMD)

In vitro and mouse studies suggest inhibiting P2RX7 or IL-1β/IL-1 receptor signaling could help treat AMD. Subretinal accumulation of chemokine CX3C motif receptor 1 (CX3CR1)-deficient mononuclear cells causes photoreceptor degeneration in AMD....

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