10:04 AM
Aug 23, 2018
 |  BC Innovations  |  Distillery Techniques

Assays and screens; imaging; drug properties

TECHNOLOGY: Cellular assays; fluorescence; drug-drug interactions

A cell-based imaging method could identify targets that promote resistance to PARP inhibitors and identify synergistic combinations of PARP and other inhibitors. The method uses fluorescent microscopy in cancer cells treated with a PARP inhibitor and siRNAs to measure changes in levels of S139-phosphorylated H2A histone family member X (H2AFX; H2AX), a marker of DNA damage response;...

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