12:59 PM
 | 
Apr 11, 2017
 |  BC Innovations  |  Distillery Techniques

Drug properties; other

TECHNOLOGY: Pharmacokinetics / pharmacodynamics; drug-drug interactions; computational models

A computational model for predicting the PK of ATRA could aid the design of ATRA-dosing strategies and identify drug-drug interactions that could help overcome resistance caused by autoinduction of ATRA clearance. The ATRA model incorporated measurements of absorption of ATRA in a human colorectal epithelial cell line and plasma samples from healthy volunteers dosed with ATRA, biodistribution of...

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