12:00 AM
Jan 15, 2015
 |  BC Innovations  |  Distillery Techniques

Techniques: Reprograming fibroblasts into sensory neurons

Disease models

TECHNOLOGY: Cell models

Direct reprogramming of fibroblasts into sensory neurons could be useful for generating new cellular models to study pain biology and screen for pain-suppressing drugs. Mouse and human embryonic fibroblasts engineered to express POU class 4 homeobox 1 (BRN3A; POU4F1) and either neurogenin 1 (Ngn1; Neurog1) or...

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