Imaging data boosts accuracy of 3-D chromosome models

The latest advance in mapping 3-D genomic structures has improved modeling by integrating an imaging technique with sequencing technology.

3-D chromatin architectures, which help regulate gene expression, are emerging targets for cancer and developmental disorders. While strategies to drug the 3-D genome are just beginning, a handful of companies have been developing tools to detect and characterize topologically associating domains (TADs), which are DNA regions that frequently interact with each other and are identified using Hi-C technology (see "Exploring 3-D Genomic White Space")...