2:56 PM
 | 
Dec 05, 2018
 |  BC Extra  |  Tools & Techniques

Proteogenomic screen identifies non-mutated tumor-specific antigens

A University of Montreal team has developed a proteogenomic screen that identifies mutated and non-mutated tumor-specific TCR antigens, including those arising from normally non-coding nucleotide sequences. The technique could help develop T cell immunotherapies targeting non-mutated, but aberantly expressed, tumor-specific antigens, which could be shared between cancer patients.

In a Science Translational Medicine paper, the researchers described the screen, a combination of transcriptomic and proteomic analyses.

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