4:01 PM
May 22, 2019
 |  BC Extra  |  Preclinical News

SR-Tiget-led team boosts ‘don’t eat me’ signals on viral vectors to improve efficacy

Boosting surface levels of a "don't eat me" signal on lentiviral vectors could enable administration of lower gene therapy doses and prevent immune responses by shielding the vectors from phagocytosis.

HIV-derived lentiviral gene therapy vectors integrate into the host genome, offering the possibility of longer-lasting gene expression than adeno-associated viral vectors. But high systemic doses have led to acute...

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