Targeting DOT1L, DUSP6 to prevent GvHD

In a Nature Communications study, scientists at University Health Network and University of Toronto showed that inhibiting histone methyltransferase DOT1L or promoting dual specificity phosphatase 6 (DUSP6; MKP3) could help prevent graft-versus-host disease induced by adoptive T cell therapy.

Adoptive T cell therapies are being developed to treat cancer but can also cause GvHD, in which the transplanted T cells proliferate and damage untargeted host tissues...