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ARTICLE | Preclinical News

Researchers identify 21 new cancer targets

August 18, 2017 7:13 PM UTC

In a paper published in Science, researchers at KTH-Royal Institute of Technology and three Swedish institutes analyzed the transcriptome of 17 major cancer types and identified 32 potential targets that could be inhibited to slow or kill tumor growth.

The team scanned RNA sequencing datasets from 9,666 individual patient tumors in The Cancer Genome Atlas (TCGA), across 17 cancers, and identified several thousand unfavorable prognostic genes, defined as genes for which higher expression was correlated with poor patient survival outcome, and where the expression level yielded a significant difference in overall survival (OS). The researchers showed shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. ...