4:29 AM
Jun 12, 2018
 |  BC Extra  |  Clinical News

Lilly, AZ stop Phase III Alzheimer's trials of BACE inhibitor

Eli Lilly and Co. (NYSE:LLY) and AstraZeneca plc (LSE:AZN; NYSE:AZN) discontinued a pair of Phase III trials evaluating once-daily oral lanabecestat (AZD3293, LY3314814) to treat Alzheimer's disease after an IDMC analysis concluded that both trials were unlikely to meet their primary endpoints. Lanabecestat is a beta-site APP-cleaving enzyme (BACE) inhibitor.

The partners stopped the Phase III AMARANTH trial in patients with early AD and the Phase III DAYBREAK-ALZ...

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