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ARTICLE | Distillery Therapeutics

Dual E3 ligase degraders enable tunable SMARCA2/4 degradation

BC Staff
June 3, 2026 12:10 AM UTC

BCIQ Target Profiles

DDB1 and CUL4 associated factor 16 (DCAF16)

SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 2 (SMARCA2) (BRM)

SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 (SMARCA4) (BRG1)

BCIQ Target Profiles

DDB1 and CUL4 associated factor 16 (DCAF16)

SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 2 (SMARCA2) (BRM)

SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 (SMARCA4) (BRG1)

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