Inhibiting SLC38A2 for hypertension

Inhibiting the neutral amino acid transporter SLC38A2 could help treat hypertension by decreasing endothelial glutamine levels, which relieves inhibition of nitric oxide production in those cells, resulting in vasorelaxation and lowered blood pressure.

RNA-sequencing analysis of primary human umbilical vein endothelial cells identified SLC38A2 as the most highly expressed amino acid transporter in that cell type. ...