Inhibiting non-muscle myosin II for axon regeneration

Inhibiting non-muscle myosin II proteins, which includes the heavy chain MYH9, could help treat axon injury by promoting axonal regeneration and reinnervation.

In human induced pluripotent stem cell (iPSC)-derived motor neurons, an axon growth assay assessing 4,557 bioactive compounds, followed by dose-dependent concentration optimization, identified the non-muscle myosin II ATPase inhibitor tool compound blebbistatin as a top candidate for promoting neurite outgrowth. ...