Inhibiting DUSP6 for colorectal cancer

Inhibiting DUSP6 — a phosphatase that dephosphorylates and stabilizes the cleaved NOTCH1 transmembrane/intracellular region, which promotes transcription of proliferation-associated genes including c-MYC and COX2 — could help treat colorectal cancer by decreasing tumor growth.

In tumor biopsies from colorectal cancer patients, DUSP6 protein expression was higher in tumors than in matched normal adjacent tissues, and higher tumor DUSP6 protein expression was associated with shorter overall survival. ...