Inhibiting GPRC5A for esophageal cancer metastasis

Inhibiting GPRC5A, a G protein-coupled receptor that regulates retinoic acid metabolism in embryonic development and relieves inhibition of YAP1 signaling, could help treat esophageal cancer metastasis by decreasing YAP1-mediated implantation of tumor cells in the lung.

Single-cell RNA sequencing of tumor cells isolated from the lungs of a xenograft mouse model of esophageal cancer metastasis comparing gene expression at two days versus two months post-intravenous injection of tumor cells identified GPRC5A as a gene whose expression is increased in early metastases compared with late metastases. ...